Effect of Daphne mucronata on Alkaline Phosphatase Enzyme and Glucose in Diabetic Rabbits

Abstract

The present study was designed to evaluate the antidiuretic potential of the aqueous leaves extract of the D. mucronata. Anti- diabetic potential of D. mucronata extracts (methanol) has been assessed in alloxan monohydrate diabetic induced rabbits. The extracts were given orally by 8 hours. The dose rate was 12 mg, 125mg, 225 mg and 325mg/kg body weight respectively. At every 2 hours blood sample was collected, serum separated and glucose level was determined by kit method. The result suggests that the treatment of 325 mg/kg body weight significantly (p<0.05) decreased blood glucose and ALP level at 143 mg/dl and 242.66 mg/dl in the experimental group. Therefore, it is concluded that the D. mucronata possess significant anti-diabetic activity.