Cardiac function profiling and its antidiabetic effect of Daphne mucronata in alloxan induced diabetic rabbits
Diabetes mellitus is a chronic hyperglycemia associated with elevated plasma cholesterol. Natural and traditional herbal remedies are a source of new commercial products. Anti- diabetic potential of D. mucronata extracts (methanol) has been assessed in alloxan monohydrate diabetic induced rabbits. The extracts were given orally by 8 hours. The dose rate was 12 mg, 125mg, 225 mg and 325mg/kg body weight respectively. At every 2 hours blood sample was collected, serum separated and glucose level was determined by kit method. The result suggests that the treatment of 325 mg/kg body weight significantly (p<0.05) decreased blood glucose and cholesterol level at 143 mg/dl and 166.33 mg/dl in the experimental group. Therefore, it is concluded that the D. mucronata possess significant anti-diabetic activity.